Inset: ratio between the contrasts for the two gold layer thickne

Inset: ratio between the contrasts for the two gold layer thicknesses considered. (c) Optical contrast in reflection mode as a function of mica thickness for three representative wave lengths, 475 nm (blue lines), 550 nm (green lines), and 650 nm (red lines), Cisplatin datasheet and two gold layer thickness,

20 nm (continuous lines) and 300 nm (dashed lines). (d) Evolution of the mica color (lines) as a function of its thickness in the xy chromatographic space for the case of semitransparent (black line) and opaque (red line) gold substrates. (1) where (2) with (3) and (4) Here, λ is the wavelength of light, and d 2 and d 3 are the thicknesses of the mica and gold layers, respectively. For simplicity, the glass substrate is assumed to be infinitely thick. Moreover, ñ j  = n j  − ik j is the complex index of refraction of material j (where we use j = 1 for air, j = 2 for mica, j = 3 for gold, and j = 4 for glass) with n being the real part

(index of refraction) and k the imaginary part (extinction coefficient). We have taken ñ 1 = 1 + i0 for air, ñ 2 = 1.55 + i0 for mica [2], ñ 3(λ) = n(λ) − ik(λ) for gold with tabulated values taken from [6], and ñ 4 = 1.52 + i0 for glass. From the reflectance, we can define the optical contrast as: ACP-196 concentration (5) In Equations 1 to 5, we have considered a non-null transmission of the gold layer in order to include the case of semitransparent gold. Figure  1a shows the reflectance spectra for the gold substrate and the mica flakes obtained from Equations 1 to 4. We

have considered two representative thicknesses for the gold layer, that is, 20 nm (continuous lines) and 300 nm (dashed lines), and different mica thicknesses, namely 0 nm (black lines, bare gold), 10 nm (red lines), 30 nm C1GALT1 (blue lines), and 50 nm (green lines). The gold thickness of 20 nm represents a semitransparent layer, enabling some light transmission, while the 300-nm-thick gold represents an opaque layer (no light transmission). By comparing the black lines (gold substrate) with the colored lines (mica flakes of different thickness), we observe that the presence of thin mica flakes can significantly modify the reflectivity of the gold substrates and that the reflectance varies as a function of the mica thickness. This means that the presence of mica sheets, and their thickness, should be measurable by reflection optical microscopy directly on gold substrates. The precision of the thickness measurement depends on the thickness of the gold layer and on the wavelength range.

gingivalis resulted in a caspase-3 activity level similar to the

gingivalis resulted in a caspase-3 activity level similar to the negative untreated control. These results are in accordance with our previous results, confirming that challenge with live, but not heat-killed, P. gingivalis at an MOI:100 for 24 hours can induce apoptosis in human gingival

epithelial cells. Figure 2 FIENA was used to detect caspase-3 activation, a key molecule in initiation of apoptosis. HGECs were challenged with live or heat-killed P. gingivalis 33277 at MOI:10 and MOI:100 for 4 and 24 hours. Negative control was unchallenged HGECs. Positive control was HGECs challenged with camptothecin 4 μg/ml. Values represent the means ± SD of at least two experiments. Statistical comparisons are to the unchallenged negative control cells (* P < 0.05, ** P < 0.01). HGECs challenged with live P. gingivalis MK0683 supplier undergo DNA fragmentation in a time- and dose-dependent manner HGECs were challenged with live or heat-killed P. gingivalis 33277 at an MOI:10 and MOI:100 for 4, 24 and 48 hours and DNA fragmentation was detected by ELISA, as well as by TUNEL. Untreated

cells were used as a negative control and cells treated with camptothecin or DNase 1000 U/ml were used as a positive control. Once the caspase cascade has been activated, the inhibitor of caspase-activated DNase (ICAD) is cleaved liberating this DNase and resulting in fragmentation of the chromosomal DNA. The Cell Death Detection ELISA can detect internucleosomal degradation of genomic DNA during apoptosis and BVD-523 price provide relative quantification of histone-complexed DNA fragments (mono- and oligo-nucleosomes). There was no significant increase in DNA fragmentation after 4 hours challenge with live or heat-killed bacteria (Fig. 3). However, 24 hours challenge with live P. gingivalis, resulted in DNA fragmentation 3-fold higher than the negative control. On the other hand, 24 hours challenge with heat-killed P. gingivalis resulted in negligible increase in DNA fragmentation, suggesting that, although some apoptosis is evident after challenge with Telomerase heat-killed bacteria, the effect is not statistically significant (Fig. 3). At 48 hours, DNA fragmentation was at similar levels as at 24 hours. These results

were also confirmed by TUNEL. The TUNEL assay measures and quantifies apoptosis by labeling and detection of DNA strand breaks in individual cells by fluorescence microscopy. The assay uses an optimized terminal transferase (TdT) to label free 3′OH ends in genomic DNA. Cells challenged with live or heat-killed bacteria at an MOI:10 did not show any positive staining at any time point (data not shown). Cells challenged with live or heat-killed bacteria at an MOI:100 did not show any positive staining at 4 hours (data not shown). The epithelial cells appeared morphologically normal under all of the above conditions. However, the cells challenged with live P. gingivalis at an MOI:100 for 24 hours showed signs of blebbing and pyknotic nuclei and stained positive for TUNEL (Fig.

g vitamins and minerals) [8] It is well established that the ut

g. vitamins and minerals) [8]. It is well established that the utilization of ingested nutrients for energy is inversely related to the thermogenesis of food. This is a phenomenon associated with the energy cost of nutrient absorption, processing and storage [9]. The loss of energy is highest for protein consisting of a 25-30% loss of the ingested energy, followed by CHO with a 6-8% loss and fat with only a 2-3% loss [10, 11]. Consequently, a higher thermogenic

response following the intake of protein compared to mTOR inhibitor CHO and fat may make some contribution to weight reduction. Therefore, the purpose of the present study was to examine the effects of a 4-week weight reduction comparing two different click here energy deficit diets with a moderately high protein intake on body composition, hormone concentration and strength performance in physically active normal weighted women. According to the literature there are no previous studies conducted with these settings in normally built non-competitive female athletes. Methods Subjects Healthy normal weighted young women were recruited for the study that had at least six months history of recreational resistance and aerobic training. The suitability of the volunteers was determined with a questionnaire.

The subject was excluded if she was a competitive athlete or she self-reported anorexia nervosa, coronary heart disease, an irregular menstrual cycle or administration of hormonal contraceptives during the last six months. The study was approved by the local University Ethics Committee and the accepted participants (n = 15) signed a written consent. Study design At the beginning of the study the subjects were randomized to two groups: group 1 KG n = 8; age 28.0 ± 6.4 yr, height 167.0 ± 6.9 cm, body mass 66.9 ± 4.3 kg, body mass index 24.0 ± 1.5, and group 0.5 KG n = 7; age 28.9 ± 6.2 yr, height 167.0 ± 7.1 cm, body mass 65.7

± 4.0 kg, body mass index 23.6 ± 2.0; mean ± SD. Farnesyltransferase The group 1 KG (energy deficit 1100 kcal/day) was supervised to reduce body weight by 1 kg per week and the group 0.5 KG (energy deficit 550 kcal/day) by 0.5 kg per week during four weeks, respectively. Vitamin and mineral supplements (but not other e.g. sport drinks, creatine) were allowed and instructed to be used during the study period. Study design is shown in Figure 1. Figure 1 Study design. Instructions, Familiarization and Weight Reduction One week before the beginning of the four week diet the subjects had a familiarization session with the exercises used in the strength tests and received general instructions for the study. The subjects kept food and training diaries during the next four days. The food diaries were analyzed using the Micro Nutrica nutrient-analysis software (version 3.11, Social Insurance Institution of Finland).

The specific productivity decreased at radiation doses less than

The specific productivity decreased at radiation doses less than 1.5 Gy. In contrast, the BDW yield decreased with increasing irradiation dose and energy up to 4.5 Gy and 60 MeV u-1 respectively. Figure 3D depicts the BDW and productivity of the strains with respect to different energy (45, and 60 MeV u-1) versus an irradiation dose at a LET of 120 keV μm-1. As the radiation dose (0.5–4.5 Gy) and energy (60 MeV μm-1) increased, the BDW yields decreased from 7.20 to 1.26 g L-1. However, the maximum specific productivity was measured at just 0.27 mg L-1 h-1. Further increases in radiation doses resulted in decreased BDW and specific productivity.

Wnt inhibitor The wild type strain of D. natronolimnaea svgcc1.2736 was used in this study to substantiate the findings made with irradiated strains. Just 20 cell cultures using wild type strains were carried out. This resulted in the wild type strains displaying a higher standard deviation (Figure 3A–D) compared with the standard deviation of the 40 irradiated strains. INK 128 research buy Throughout the study, it was observed that the BDW declined concomitantly with increasing bacterial specific productivity. The BDW dropped to its minimum when microorganism specific productivity peaked. From our findings it is evident that irradiation doses (120 keV μm-1 of LET

and 60 MeV u-1 of energy level) greater than 4.5 Gy can both damage cells and/or change cell morphology, which leads to reduced CX yields. The optimal LET, Energy and irradiation dose for the non-lethal induction of point mutations by 12C6+ ions (LET=80 keV μm-1, energy=60 MeV u-1 and dose=0.5–4.5 Gy) are also ideal for maximising CX specific productivity in D. natronolimnaea svgcc1.2736. Figure 3 Obatoclax Mesylate (GX15-070) Influence of different irradiation dose (energy=45,60 MeV/u) on the D. natronolimnaea svgcc1.2736 strains biomass dry weight

and productivity. (A) LET for 60 keV/μm post-irradiation, 72 hours of cultivation illustrating the effect of biomass dry weight and specific productivity. (B) LET for 80 keV/μm post-irradiation, 72 hours of cultivation illustrating the effect of biomass dry weight and specific productivity. (C) LET for 100 keV/μm post-irradiation, 72 hours of cultivation illustrating the effect of biomass dry weight and specific productivity. (D) LET for 120 keV/μm post-irradiation, 72 hours of cultivation illustrating the effect of biomass dry weight and specific productivity. Statistical evaluation and optimization of factors affecting productivity by RSM Canthaxanthin production is generally carried out through fermentation processes [48]. Because of their ease of manipulation microorganisms provide an excellent system that facilitates large-scale production of CX. Optimization of conditions favouring CX production in irradiated strains is necessary to explore their industrial possibilities [49]. This can be achieved through RSM, a type of modelling used to study the effects of simultaneous variation of several factors [50].

J Allergy Clin Immunol 92(3):387–396CrossRef Bernstein DI, Cartie

J Allergy Clin Immunol 92(3):387–396CrossRef Bernstein DI, Cartier A, Cote J, Malo JL, Boulet LP, Wanner M, Milot J, L’Archeveque J, Trudeau

C, Lummus Z (2002) Diisocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficiency than specific antibodies for identification of diisocyanate asthma. Am J Respir Crit Care Med 166(4):445–450CrossRef Brandli O, Schindler C, Kunzli N, Keller R, Perruchoud AP (1996) Lung function in healthy never smoking adults: Veliparib cell line reference values and lower limits of normal of a Swiss population. Thorax 51(3):277–283CrossRef Brandli O, Schindler C, Leuenberger PH, Baur X, Degens P, Kunzli N, Keller R, Perruchoud AP (2000) Re-estimated equations for 5th percentiles of lung function variables. Thorax 55(2):173–174CrossRef Budnik LT, Nowak D, Merget R, Lemiere C, Baur X (2011) Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies. J Occup Med Doramapimod Toxicol 6(1):9–18CrossRef Campo P, Wisnewski AV, Lummus Z, Cartier A, Malo JL, Boulet LP, Bernstein DI (2007) Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI-exposed workers. Clin Exp Allergy 37(7):1095–1102CrossRef Curwick CC, Bonauto DK, Adams DA (2006) Use of objective testing in the diagnosis of work-related asthma by physician specialty.

Ann Allergy Asthma Immunol 97(4):546–550 Hendrick DJ (2002) Diagnostic tests for occupational asthma. Am J Respir Crit Care Med 166(4):436–437CrossRef Hur GY, Koh DH, Choi GS, Park HJ, Choi SJ, Ye YM, Kim KS, Park HS (2008) Clinical and immunologic findings of methylene diphenyl diisocyanate-induced occupational asthma in a car upholstery factory. Clin Exp Allergy 38(4):586–593CrossRef Jayet PY, Schindler C, Kunzli N, Zellweger JP, Brandli O, Perruchoud AP, Keller R, Schwartz J, Ackermann-Liebrich U, Leuenberger P (2005) Reference Urease values for methacholine reactivity (SAPALDIA study). Respir Res 6:131CrossRef Jones MG, Floyd A, Nouri-Aria KT, Jacobson MR, Durham SR, Taylor AN, Cullinan P

(2006) Is occupational asthma to diisocyanates a non-IgE-mediated disease? J Allergy Clin Immunol 117(3):663–669CrossRef Kumar A, Dongari N, Sabbioni G (2009) New isocyanate-specific albumin adducts of 4,4′-methylenediphenyl diisocyanate (MDI) in rats. Chem Res Toxicol 22(12):1975–1983CrossRef Lushniak BD, Reh CM, Bernstein DI, Gallagher JS (1998) Indirect assessment of 4,4′-diphenylmethane diisocyanate (MDI) exposure by evaluation of specific humoral immune responses to MDI conjugated to human serum albumin. Am J Ind Med 33(5):471–477CrossRef Maestrelli P, Boschetto P, Fabbri LM, Mapp CE (2009) Mechanisms of occupational asthma. J Allergy Clin Immunol 123(3):531–542CrossRef Malo JL, Chan-Yeung M (2009) Agents causing occupational asthma.

Table 1 Results from studies of biodiversity effects on productio

Table 1 Results from studies of biodiversity effects on production and further ecosystem services in grassland with some form of agricultural management Talazoparib cell line Management Country Plant diversity Production Further ecosystem services References Rotational grazing (dairy

cows), no fertiliser, clipping of excessive ungrazed forage Pennsylvania, USA 2–9 sown species 0 (herbage intake, milk production) + (higher conjugated linoleic acid content of milk with more species) Soder et al. (2006) Rotational grazing (beef cattle) Illinois, USA 3–8 sown species 0 (stocking rate, average daily gain, despite initially higher herbage mass in more diverse plots before grazing) n.d. Tracy and Faulkner (2006) Rotational grazing (to different target heights), mowing Pennsylvania, USA 1–7 sown species 0 (in favourable years higher yields in fertilised monocultures) + (more consistent

yields in diverging weather conditions, improved CP and IVTDMD at first harvest, more stable quality of complex mixtures over season) Deak et al. (2009) Montane semi-natural grassland (78 plots under agricultural management, grazed or cut) Germany 8–33 species; average of 20 species 0 (for species selleck chemicals richness as well as effective diversity and Camargo’s evenness) plant community composition explained productivity n.d. Kahmen et al. (2005) Park grass experiment, different fertilisation treatments since 1856 with N, P or K, two cuts (initially one cut followed by grazing) England 3–44 species per 200 m² − (less species numbers with more production) + (stability of hay biomass was positively correlated with species number, albeit weakly) Silvertown et al. (2006) Experimental restoration sites (sown on arable land, no weeding), late cut with autumn and winter sheep-grazing England Mixtures with 6–17 or 25–41 species

(species-poor and -rich, respectively) + (linear relationship between difference in species number among treatments and increase in hay yield) 0 (no effect on fodder quality) Bullock et Thymidylate synthase al. (2001) Experimental plots, no weeding, one cut/year, followed over 9 years The Netherlands 0–15 sown species, on average 10 to 14 species in total + (productivity increased with number of sown species) However, if total species number was considered, there was no clear relationship + (stability increased with sown species number, but not with total species number) Bezemer and van der Putten (2007) Experimental plots, rotational or continuous grazing, initial weeding during establishment New Zealand 0–8 functional groups + (for sown species in spring) 0 (for total species production in spring as well as total and sown species production in autumn) + (resistance to invasion, resilience to disturbance) Dodd et al. (2004) Indoor cafeteria experiment with sheep China 1–11 species + (more voluntary average daily intake of sheep with higher diversity) n.d. Wang et al.

Renal dysfunction and albuminuria in CKD patients have been estab

Renal dysfunction and albuminuria in CKD patients have been established as a risk factor for cardiovascular (CV) events

independent of conventional CV risk factors [6–8]. Population-based studies in Western and Asian countries have shown that the risk of CVD increases as renal function declines. Because of this finding, the National Kidney Foundation formed a task force to heighten awareness of CVD in CKD, and defined CKD using parameters such as decreased eGFR < 60 ml/min/1.73 m2. A cohort of CKD patients treated by nephrologists is required to accurately analyze renal and CV events. However, few studies have been conducted on the SP600125 prevalence of left ventricular hypertrophy (LVH) in a predialysis population [9–12]. The aim of the present study was to clarify whether there is a close correlation between the prevalence of LVH and the stage of CKD classified according to eGFR and to identify factors related to LVH among the participants in the Chronic Kidney Disease Japan Cohort (CKD-JAC) [13]. Subjects and methods Inclusion and exclusion criteria Baseline characteristics of CKD-JAC are described elsewhere [14]. The following inclusion criteria were used at screening: (1) Japanese or Asian patients living in Japan; (2) age 20–75 years; and (3) a broad spectrum of CKD with eGFR of 10–59 ml/min/1.73 m2. eGFR was calculated

using a modified three-variable equation for eGFR in Japanese patients [15]: eGFR = 194 × age−0.287 × sCr−1.094 Fludarabine order Staurosporine concentration (×0.739, if female), where sCr = serum creatinine. All patients were classified on the basis of CKD stage as described in our previous

paper [13]. The following patients were excluded from participation: (1) patients with polycystic kidney disease, human immunodeficiency virus (HIV) infection, liver cirrhosis, active cancer, and patients who had received cancer treatment within the past 2 years; (2) transplant recipients and patients who had previously been on long-term dialysis; (3) patients who refused to provide informed consent. Information on past medical history, including hypertension, acute myocardial infarction, angina pectoris, congestive heart failure, peripheral arterial disease, cerebrovascular disease, and prescription of antihypertensive agents, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), diuretics, and β-blockers, statins, and antiplatelet agents, was collected from the medical records at each institution. Blood pressure and echocardiographic measurements Blood pressure (BP) was measured in outpatient clinics with an automated sphygmomanometer after a 5-min rest. BP in the right arm was measured three times at intervals of 1 min, and the mean values were used for analyses. A mercury sphygmomanometer was used to measure the BP of patients who had frequent premature contractions, atrial fibrillation, or atrial flutter. Pulse pressure was calculated by subtracting diastolic BP from systolic BP.

BMC Genomics 2011, 12:261 PubMedCrossRef 27 Petersen L, Bollback

BMC Genomics 2011, 12:261.PubMedCrossRef 27. Petersen L, Bollback J, Dimmic

M, Hubisz M, Nielsen R: Genes under positive selection in Escherichia coli. Genome Res 2007,17(9):1336–1343.PubMedCrossRef 28. Farfán M, Miñana-Galbis D, Fusté M, Lorén JG: Divergent evolution and purifying selection of the flaA gene sequences in Aeromonas. Biol Direct 2009, 4:23.PubMedCrossRef 29. Jiggins F, Hurst G, Yang Z: Host-symbiont conflicts: positive selection on an outer membrane protein of parasitic but not mutualistic Rickettsiaceae. Mol Biol Evol 2002,19(8):1341–1349.PubMedCrossRef 30. Snijder H, Ubarretxena-Belandia I, Blaauw M, Kalk K, Verheij H, Egmond M, Dekker N, Dijkstra B: Structural evidence for dimerization-regulated activation of an integral membrane phospholipase.

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Recent studies suggest that BRCA proteins are required for protec

Recent studies suggest that BRCA proteins are required for protecting the genome from damage [12]. Mutations in BRCA genes have been established to predispose women to breast and ovarian cancer, the end point of BRCA protein

dysfunction. Mutations in both genes are spread throughout the entire gene. More than 600 different mutations have been identified in BRCAl gene and 450 mutations in BRCA. The majorities of mutations, known to be disease-causing, find more results in a truncated protein due to frame shift, nonsense, or splice site alternations. Nonsense mutations occur when the nucleotide substitution produces a stop codon (TGA, TAA, or TAG) and translation of the protein is terminated at this point. Frame shift mutations occur when one or more nucleotides are either inserted or deleted, resulting in missing or non-functional protein. Splice

site mutations cause abnormal inclusion or exclusion of DNA in the coding sequence, resulting in an abnormal protein. Other kind of mutations results from a single nucleotide substitution is missense mutations in which the substitution changes a single amino acid but does not affect the remainder of the protein translation [13, 14]. Studies of BRCAl mutation occurrence suggested that nearly half of the families at high risk for breast cancer carried BRCAl mutation [15]. However, other analysis suggest that the actual incidence of BRCAl in high risk families (>3 cases of breast and/or ovarian check details cancer) might be as low as 12.8% to 16% [4]. Substantial variation in the prevalence of BRCA1 mutations in high risk families in various

countries has been observed which are more common than BRCA2 mutations [16, 17]. The main objectives of the present work were to identify germline mutations in BRCA1 (exons 2, 8, 13, 22) and BRCA2 (exon 9) genes for the early detection of presymptomatic mutation carriers in Egyptian healthy females who were first degree relatives of affected women from families with and without family history of breast cancer. Subjects and Methods Patients and families Sixty breast cancer patients (index patients), Ribose-5-phosphate isomerase derived from 60 families, considered being at high risk, due to medicinal examination and they were grid 3 patients, were selected for molecular genetic testing of BRCA1 and BRCA2 genes. They were referred to the Clinical Oncology Unit in Medical Research Institute, Alexandria University, for chemotherapy as part of their curative treatment after mastectomy. Selected index patients were preferred to be at early onset age at diagnosis, possessing a positive family history and bilateral breast cancer. The study also included one hundred and twenty healthy first degree female relatives of index patients either sisters and/or daughters for early detection of mutation carriers. The decision to undergo genetic testing was taken after the participants were informed about benefits and importance of genetic testing.

J Luminesc 1996, 69:287–294 10 1016/S0022-2313(96)00107-XCrossRe

J Luminesc 1996, 69:287–294. 10.1016/S0022-2313(96)00107-XCrossRef 9. Gratian

RB, Takashi U, Yoshimoto A, Kazuhiro S, Hironori A: The photocatalytic oxidation of water to O 2 over pure CeO 2 , WO 3 , and TiO 2 using Fe 3+ and Ce 4+ as electron acceptors. Appl Catal, A 2001, 205:117–128. 10.1016/S0926-860X(00)00549-4CrossRef 10. Ryuhei N, Akihiro O, Hitoshi O, Hiroshi I, Kazuhito H: Design of all-inorganic molecular-based photocatalysts sensitive to visible light: Ti(IV)–O - Ce(III) bimetallic assemblies AZD4547 research buy on mesoporous silica. J Am Chem Soc 2007, 129:9596–9597. 10.1021/ja073668nCrossRef 11. Zou YL, Li Y, Guo Y, Liu XL, Cai H, Li JG: Study on the photoluminescence of nano-CeO 2 . J Liaoning Norm Univ (Nat Sci Edit) 2009, 32:212–214. 12. Chen QF, Jiang D, Xu Y, Wu D, Sun YH: Visible region photocatalysis of Ce-Si/TiO 2 synthesized using sol–gel-hydrothermal method. Acta Phys -Chim Sin 2009, 25:617–623. 13. Li FB, Li XZ, Hou www.selleckchem.com/products/3-deazaneplanocin-a-dznep.html MF, Cheah KW, Choy WCH: Enhanced photocatalytic activity of Ce 3+ –TiO 2 for 2-mercaptobenzothiazole degradation in aqueous suspension for odour control. Appl Catal A 2005, 285:181–189. 10.1016/j.apcata.2005.02.025CrossRef 14. Luo L PhD Thesis. In Study on surface oxidation

of cerium metal by Xps. China: Academy of Engineering Physics; 2005. 15. Mott NF, Davis EA: Electronic Processes in Non-Crystalline Materials. 2nd edition. Oxford: Clarendon Press; 1979. 16. Kontos AI, Likodimos V, Stergiopoulos T, Tsoukleris DS, Falaras P: Self-organized anodic Galeterone TiO 2 nanotube arrays functionalized by iron oxide nanoparticles. Chem Mater 2009, 21:662–672. 10.1021/cm802495pCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions YT carried out the TiO2 nanotube arrays preparation, photoelectrochemical investigation, and SEM/XPS analysis. SZ carried out the Mott-Schottky plots analysis and calculation. KL wrote and designed the study. All authors read and approved the final manuscript.”
“Background As the world population grows, the demand for energy consumption will also increase in tandem.

In order to meet the growing demand, there is a need to use renewable energy source as an alternative source for fossil fuels. One of the renewable energy routes is solar cells. Of all the solar cell technologies, quantum dot-sensitized solar cells (QDSSCs) have emerged as a widely researched topic in recent years [1–4]. The high interest in this field is due to the attractive properties of the quantum dots (QDs), namely ease of synthesis, ability to tune the band gap energy and possibility of attaining multiple exciton generation (MEG) [3–5]. Some examples of QDs include but not limited to Ag2S [6], CdS [7], CdSe [8], PbS [9] and CuInS2[10]. Recently, QDs based on organometallic perovskites such as CH3NH3Pbl3 have shown impressive efficiencies [11]. In QDSSCs, the working principle is almost similar to that of the dye-sensitized solar cell (DSSC) [12].