Results: Thirty-seven studies were included, the majority focused on etanercept. Seven RCTs were identified, including one each for etanercept, infliximab, adalimumab, abatacept, and anakinra, and one each looking at etanercept or infliximab as first-line therapies. There was strong evidence to support the efficacy and safety of biologics over the short-term, but a lack of long-term data for treatments AZD9291 order other than etanercept. Several high-quality patient registries confirmed the efficacy and safety of etanercept over the long-term.
Conclusions:
Current evidence shows that a short-term improvement in treatment response is achieved when patients with polyarticular JIA with an inadequate response to conventional treatment are treated with biologics. Long-term effectiveness data, however, are
sparse leaving many questions regarding switches between biologics, handling patients that achieve disease remission, and long-term safety. Study designs other than RCTs may be important in understanding the role of biologics in JIA over the long-term. (C) 2013 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 42:597-618″
“We present the surface and interfacial chemical analysis of sputter deposited TiNi thin films over Si (100) substrates using Rutherford backscattering NCT-501 spectrometry (RBS), secondary ionization mass spectrometry (SIMS), and grazing incidence x-ray diffraction analysis. Upon annealing to high temperatures, significant diffusion of Ni into the Si substrate was observed. The analysis of the RBS and SIMS spectra confirm the net movement of the film species into the substrate. Further, we discuss the formation mechanism and the composition distribution surrounding the TiNi/Si Erismodegib interface that proves conducive for the nucleation and growth of the detected nickel silicide compound.”
“Aim:
To evaluate the sexual functioning of breast cancer patients post mastectomy and its association with their quality of life, the personal characteristics of women and their partners, breast reconstruction, cancer staging and adjuvant therapies.
Methods: A cross-sectional study was carried out in a University hospital located in the SouthEast of Brazil. A total of 100 women were included in the study. The parameters evaluated were sexual functioning, which was assessed based on the Sexual Quotient Female Version (SQ-F), quality of life (QoL), evaluated by the Medical Outcomes Study 36-item Short Form (SF-36), cancer staging, breast reconstruction, adjuvant therapies and the personal characteristics of patients (age, years of study and years of marriage) and their partners (age, years of study).
Results: The majority (40.48%) of women had an unfavorable to regular SQ-F score. A significant positive correlation (p < 0.05) was found between the SQ-F score and years of education (p = 0.03), and the following SF-36 domains: functional capacity (p = 0.03), vitality (p = 0.06), emotional limitations (p = 0.00) and mental health (p = 0.03).