It is well known that aspirin injures the mucosa through Cyclooxygenase inhibition and its direct effects. However, it is unclear Selleck GSI-IX whether aspirin influences the ulcer healing after ESD. Methods: We investigated 73 consecutive patients undergoing ESD for gastric neoplasm, except for 4 cases of long-term Non-steroidal anti-inflammatory drug administration patients and 5 cases that were injected triamcinolone in post-ESD ulcers for the prevention of stenosis after ESD. All cases were administered Proton pump inhibitor and performed endoscopy in four weeks after ESD. We calculated a reduction rate of ulcer in four weeks after ESD from ESD specimen size. The
size was calculated by multiplication of the major and minor diameters. We divided patients into three groups: A-group, no antithrombotics, 56 cases; B-group, aspirin, 7 cases; and C-group,
non-aspirin antithrombotics, 10 cases. We defined age, gender, tumor location, tumor depth and ESD procedure time as risk factors. Results: There is no significant difference in the risk factors among 3 groups. The residual selleck ulcer rates were 3.5 ± 4.3, 8.3 ± 16.3, and 7.6 ± 12.4 in each group, respectively. The residual ulcer rate in patients treated with antithrombotics (B+C-group: 7.9 ± 13.6) was significantly higher than that in A-group, respectively (p = 0.039). Conclusion: Aspirin may delay the ulcer healing after ESD, not through its mucosal toxicity, but it seems to be related with the antithrombotic effects, which could lead to developing ulcer bleedings after ESD common to antithrombotics. Key Word(s): 1. antithrombotics; 2. aspirin; 3. endoscopic submucosal dissection Presenting Author: SHIGENORI WAKITA Additional Authors: ISSEI TSURUDOME, RYO HIGASHIBORI, SHINNOSUKE
MIURA, AKIHISA OKADA, TATSUHIKO MABUCHI, MAMIKO TAKEUCHI, TSUTOMU HOSOI, MASAHIKO YAMADA Corresponding Author: SHIGENORI WAKITA Affiliations: Anjo Kosei Hospital, Anjo Kosei Hospital, Anjo Kosei Hospital, Anjo Kosei Hospital, Anjo Kosei Hospital, Anjo Kosei Hospital, Anjo Kosei Hospital, Anjo Kosei Hospital Objective: While a shift to home care is currently being promoted, www.selleck.co.jp/products/Decitabine.html what gastrostomy should be and its indications have again become controversial. In the study, we included patients who underwent percutaneous endoscopic gastrostomy (PEG) in our clinic. Methods: We examined underlying diseases, methods for gastrostomy, complications, and outcomes in 281 patients aged between 5 and 94 years (mean age: 73 years; 161 males and 120 females) who underwent PEG in our clinic for five years between January 2009 and December 2013. Results: The most common underlying disease was cerebrovascular disorders in 111 patients (39.5%), followed by neurodegenerative diseases in 66 (23.5%), dementia in 47 (16.