Diabetes of the offspring is also mainly the consequence of exposure to the
diabetic intrauterine environment, in addition to genetic susceptibility. Since obesity and diabetes are known to increase the risk of cardiovascular disease, cardiovascular sequelae in the offspring of diabetic mothers are virtually inevitable. Research data also suggest that exposure to a diabetic intrauterine environment during pregnancy is associated with an increase in dyslipidemia, subclinical vascular inflammation, and endothelial dysfunction processes in the offspring, all of which are linked with development of cardiovascular disease later in life. The main underlying mechanisms involve persistent hyperglycemia hyperinsulinemia BIIB057 and leptin resistance.”
“The present study evaluates the causes for the persistence of symptoms and radiological signs after at least 2 months of intensive anti-tuberculosis treatment in children. In this
prospective observational study, 26 paediatric patients with partial or no response to anti-tuberculosis treatment after the 2-month intensive phase were enrolled. After a detailed history and workup, it was found that 9 (34.6%) patients had a wrong initial diagnosis, while 12 (46.2%) had either received inadequate treatment or had complications requiring prolonged buy Wortmannin treatment; 5 (19.2%) failed to respond. Failure to respond to anti-tuberculosis treatment in paediatric AZD6244 molecular weight tuberculosis seems to be over-diagnosed.”
“A 5-year-old boy with an unremarkable past medical and family history presented with recurrent syncope precipitated by physical activity. Electrocardiogram performed in the emergency room after one of his episodes revealed atrial flutter. He had a structurally normal heart. Exercise stress test revealed atrial fibrillation with rapid ventricular response immediately on commencement of running. Atrial fibrillation subsequently organized into atrial flutter with variable ventricular
response followed by spontaneous conversion to sinus rhythm. This case highlights the use of exercise stress test in a preschool child to elicit an unusual cause of syncope.
(PACE 2009; 32:416-418).”
“In this paper we investigated the most important family of proton conducting oxides, i.e., cerates, by means of neutron diffraction and of pair distribution function analysis (PDF). The paper describes the structural effects of Y-doping and water incorporation in cerates proton conductors from a viewpoint of the average structure (determined from diffraction) and the local structure (determined from PDF analysis). (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3148864]“
“Introduction.