Consequently Overall columns in Table 4 (and analogously in Table 5) do not correspond to an average of the line-specific columns because patients can move across tablesa. These methodological considerations are
done here to justify why results will not be commented separately per single line of treatment, when patients are analyzed with any/no response to systemic therapy. Summarizing, though the length of the follow-up period varies among sample patients, an amount of the yearly cost click here per patient can be estimated, dividing the average per patient total cost (€ 5.040) by the average follow-up duration (17.5 months) and reporting to one year; on these grounds, unresectable stage III or stage IV melanoma in Italy would cost € 3,456 per patient per year. Hospice care Approximately 6% of patients received hospice care with a mean cost per admitted patient of € 3.300. Due to the low frequency of such resource use, the mean cost for the generality of the sample is quite low (€ 184). Emergency room visit Emergency room visits were very rare: overall 1.4% of patients had one or more visit. www.selleckchem.com/products/AZD1152-HQPA.html Consequently the mean cost for
the generality of the sample is very low (€ 4). Outpatient visit Outpatient visits were the most common category of resource utilization: 40.5% of patients had at least one visit, with 3.3 visits per patient (Overall) on average. As compared with other major categories of utilization, outpatient visits were relatively inexpensive, with a mean cost of € 70 per visited patient and a mean cost for the generality of the
sample of € 28 (Table 6). Outpatient visits were Chorioepithelioma more check details frequent in patients with any response to systemic therapy, where the mean cost per patient was higher than the mean cost per non responder patient (€ 33 vs € 22). Table 6 Summary statistics for outpatient visits for patients receiving systemic therapy and/or supportive care Overall First-line therapy Second-line therapy Third-line therapy Supportive care N 215 147 112 41 24 Patients with any outpatient visits N 87 44 36 19 15 % 40,5% 29,9% 32,1% 46,3% 62,5% Total number of outpatient visits per visited patient Mean 3,3 2,4 2,5 2,5 2,7 95%CI 2,8-3,7 2,1-2,8 2-3 1,8-3,2 1,9-3,4 Total number of outpatient visits per visited patient per month (1) Mean 0,3 0,5 0,6 0,5 3,3 95%CI 0,2-0,4 0,3-0,7 0,3-0,9 0,4-0,7 0-7,1 Total outpatient cost per visited patient (€ 2009) Mean 70 50 60 50 60 95% CI 60-80 50-60 40-70 40-70 40-80 Total outpatient cost per visited patient per month (€ 2009) Mean 7 11 13 11 73 95% CI 4-9 7-15 7-20 9-15 0-156 Total outpatient cost per patient (€ 2009) Mean 28 15 19 23 38 (1) month of follow-up.