Setting: Nine outpatient rehabilitation centres in the Netherlands. Participants: Patients with a stroke who had been discharged home and who could walk 10 m without assistance were included. Cognitive deficits and inability to communicate were key exclusion criteria. Randomisation of 250 participants KPT-330 clinical trial allocated 126 to task oriented circuit training and 124 to individualised physiotherapy. Interventions: The task oriented circuit training group trained for 90 min twice-weekly for 12 weeks supervised by physiotherapists and sports trainers as they completed 8 mobility-related stations in groups of 2 to 8 participants.

Individualised outpatient physiotherapy was designed to improve balance, physical conditioning, and walking. Outcome measures: The primary outcome was the mobility domain of the stroke impact scale measured at 12 weeks and 24 weeks. The domain includes 9 questions about a patient’s perceived mobility competence and is scored from 0 to 100 with higher scores indicating better mobility. Secondary outcome measures included selleck products other domains of the stroke impact scale, the Nottingham extended ADL scale, the falls efficacy scale, the hospital anxiety and depression scale, comfortable walking speed, 6-minute walk distance, and a stairs test. Results: 242 participants completed the study. There were no differences in the mobility domain of the stroke impact scale between the groups at 12 weeks (mean difference (MD)

–0.05 units, 95% CI –1.4 to 1.3 units) or 24 weeks (MD –0.6, 95% CI –1.8 to 0.5). Comfortable walking speed (MD 0.09 m/s, 95% CI 0.04 to 0.13), 6-minute walk distance (MD 20 m, 95% CI 35.3 to 34.7), and stairs test (MD –1.6 s, 95% CI –2.9 to –0.3) improved a little more in the circuit training group than the control group at 12 weeks. The memory and thinking domain of the stroke impact scale (MD –1.6 units, 95% CI –3.0

to –0.2), and the leisure domain of the Nottingham extended ADL scale (MD –0.74, 95% CI –1.47 to –0.01) improved a little more in the control group than the circuit training group at 12 weeks. The groups did not differ significantly on the remaining secondary outcomes at 12 weeks or 24 weeks. next Conclusion: In patients with mild to moderate stroke who have been discharged home, task oriented circuit training completed in small groups was as effective as individual physiotherapy in improving mobility and may be a more efficient way of delivering therapy. [95% CIs calculated by the CAP Co-ordinator] Evidence that task-specific circuit training may improve walking after stroke has been growing since the first pilot study published in 2000 (Dean et al 2000). From research into motor learning and several meta-analyses of rehabilitation we know that increasing the amount of practice will improve outcome. However repeated behavioural observation studies have shown low levels of physical activity during rehabilitation after stroke.