Results-The ketamine-propofol group had a significantly higher mean heart rate at several time points during drug infusion, a significantly shorter time from the end of infusion to extubation (7 vs 29 Selleckchem Fer-1 minutes), and significantly lower sedation scores for the first hour after surgery than did the ketamine-propofol-dexmedetomidine group.
Other variables were similar between groups; recovery was smooth, and anesthesia and postoperative analgesia were deemed adequate for all cats. The number of RBCs with Heinz bodies was not increased after surgery, compared with values immediately after anesthetic induction.
Conclusions and Clinical Relevance Total IV anesthesia with a ketamine-propofol combination, with or without dexmedetomidine, appeared to be effective in healthy cats. These short-term infusions produced smooth recovery and adequate analgesia during the postoperative period. (J Am Vet Med Assoc 2012;241:1307-1313)”
“The angular dependence
of the remanence and coercivity of Ni nanowire arrays produced inside the pores of anodic alumina membranes has been studied. By comparing our analytical calculations with our measurements, we conclude that the magnetization reversal in this array is driven by means of the nucleation and propagation of a transverse wall. A simple model based on an adapted Stoner-Wohlfarth model is used to explain the angular dependence of the coercivity. (C) 2009 American Institute of Physics. [doi:10.1063/1.3257242]“
“Background: NSC23766 Evidence suggests anti-inflammatory effects of glucosamine (GS) on inflammatory diseases. COX-2 is an enzyme to produce prostaglandins. MMPs are the family of matrix metalloproteinases degradable of ECM. Excess expression of COX-2 or MMPs involves in skin inflammation.
Objective: We evaluated whether GS-HCl modulates expression of COX-2 and/or MMPs by IL-1 beta or PMA in human skin fibroblasts (HSF) or keratinocytes (HaCaT).
Methods: HSF or HaCaT cells were exposed to IL-1 beta
or PMA without or with GS-HCl. COX-2 or MMPs protein and mRNA expression, respectively, were analyzed by Western blot and RT-PCR. MTS assay was utilized to assess the cytotoxicity of GS-HCl on HSF cells.
Results: In HSF cells, IL-1 beta treatment induced COX-2 and MMP-13 expressions SCH727965 cell line in association with activation of ERKs, p38 MAPK, JNKs, and NF-kappa B. PMA treatment also induced COX-2 and MMP-13 expressions in association with p38 MAN activation. Of interest, treatment with GS-HCl (10 mM) led to blockage of p38 MAPK activation, accumulation of 66 kDa COX-2 protein variant (without affecting COX-2 mRNA expression), and transcriptional down-regulation of MMP-13 in the IL-1 beta- or PMA-treated HSF cells. Distinctly, pharmacological inhibition of p38 MAPK with SB203580 was associated with transcriptional down-regulation of COX-2 and MMP-13 in the IL-1 beta- or PMA-treated HSF cells.