Men without MS had significantly lower leptin/adiponectin ratio than men with MS. Women without MS had lower leptin Sapanisertib order and leptin/adiponectin ratio than women with MS but had significantly higher adiponectin, estrone, and dehydroepiandrosterone levels. In men, the leptin/adiponectin ratio is the main

factor associated to MS diagnosis (OR: 3.36, 95% CI 1.40-8.08), while in women adiponectin alone appears to be a protective factor (OR: 0.87, 95% CI 0.79-0.95). In conclusion, in a sample of pharmacologically untreated subjects, leptin/adiponectin ratio seems to be the factor more strongly associated to MS and its components.”
“Two new friedelane type triterpenoids, ovalifolone JNK assay A (1) and ovalifolone

B (2), together with eight known compounds were isolated from the stem bark of Garcinia ovalifolia. Their structures were established on the basis of mass spectrometric, NMR data and by the comparison with literature data. Some of the isolated compounds were evaluated for their cytotoxicity and antibacterial activities and garcinane showed interesting activity against Artemia salina with LD50 value of 2.69 mu g/mL. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.”
“Background. There are limited data on sleep duration and diabetes from developing countries. We therefore examined the relationship between reported hours of sleep, diabetes prevalence and glucose control in Jamaican adults. Methods. Data on reported hours of sleep

and diabetes (based on glucose measurement and medication use) from a national survey of 15-74-year-old Jamaicans were analyzed. Results. The 2,432 participants (31% M, Age 42 +/- 16 years, BMI 27.6 +/- 6.6 kg/m(2), diabetes prevalence 12%) reported sleeping 8.2 +/- 1.8 hours. In men, sleeping less than 6 hours (OR (95% CI) = 2.65 (1.09-6.48)) or more than 10 hours (OR (95% CI) = 4.36 (1.56-12.19)) was associated with diabetes when adjusted for age, BMI, and family history of diabetes. In women sleeping less than 6 hours was associated with a reduced likelihood of Selleckchem Proteasome inhibitor diabetes after adjusting for the same confounders ((OR (95% CI) = 0.43 (0.23-0.78)). There was no significant association between sleep and glucose control. Conclusion. Insufficient and excessive sleep was associated with increased diabetes prevalence in Jamaican men but not women.”
“Cordylactam (1), a new lactam-fused 4-pyrone was isolated from the spider pathogenic fungus Cordyceps sp. BCC 12671. The structure was elucidated on the basis of NMR spectroscopic and mass spectrometry data, which was further confirmed by the spectroscopic analyses of a semisynthetic derivative. This is the first report of a new compound from spider pathogenic Cordyceps species. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.