Findings highlight the need for context sensitive malaria control

policies; not only to reduce the local malaria burden but also to minimize the risk of AZD8931 malaria spreading to other areas where transmission has virtually ceased.”
“Prior single-center studies have reported that pancreas allograft survival is not affected by preservation in histidine-tryptophan-ketoglutarate (HTK) versus University of Wisconsin (UW) solution. To expand on these studies, we analyzed the United Network for Organ Sharing (UNOS) database of pancreas transplants from July 2004, through February 2008, to determine if preservation with HTK (N = 1081) versus UW (N = 3311) impacted graft survival. HTK preservation of pancreas allografts increased significantly in this time frame, from 15.4% in 2004 to 25.4% in 2008. After adjusting for other recipient, donor, graft and transplant center factors that impact graft survival, HTK preservation

was independently associated with an increased risk of pancreas graft loss (hazard ratio [HR] 1.30, p = 0.014), especially in pancreas allografts with cold ischemia time (CIT) >= MK-0518 12 h (HR 1.42, p = 0.017). This reduced survival with HTK preservation as compared to UW preservation was seen in both simultaneous pancreas-kidney (SPK) transplants and pancreas alone (PA) transplants. Furthermore, HTK preservation was also associated with a 1.54-fold higher odds of early (< 30 days) pancreas graft loss as compared to UW (OR 1.54, p = 0.008). These results suggest that the

increasing use of HTK for abdominal organ preservation should be re-examined.”
“Background: Survival analysis of a large series of patients with mycosis fungoides (MF) and Sezary syndrome (SS) has not been performed in Japan. Revision to the staging system for MF and SS was recently published.

Objective: To determine the long-term prognosis of Japanese patients with MF and SS, to identify factors predictive HM781-36B molecular weight of survival, and to evaluate the prognostic significance of the revised staging system.

Methods: We performed a retrospective cohort study of 100 Japanese patients with MF and SS managed at the dermatology division of Niigata University Hospital between April 1, 1982 and March 31, 2006. We estimated survival according to the patient’s clinical characteristics including the stages, and assessed their prognostic significance.

Results: Survival rates of Japanese patients with MF and SS were similar to those shown in previous studies conducted in the United States and Europe. Prognosis of patients with skin tumor (stage IIB) and extracutaneous involvement (stage IV) was significantly worse than that of those with early-stage disease (stages IA-IIA), but erythrodermic MF patients without blood involvement (stage IIIA) showed excellent survival.