Conclusions: After a mean of 7.5 years of follow-up, patients undergoing off-pump coronary artery bypass performed better than those undergoing cardiopulmonary bypass in several neuropsychological domains; these differences were small and of uncertain clinical importance. Early brain magnetic resonance imaging showed no significant differences in acute cerebral infarctions between the off-pump coronary artery bypass and cardiopulmonary bypass groups. (J Thorac Cardiovasc Surg 2011; 141: 1116-27)”
“To develop a safe and efficient vaccine for the treatment of Alzheimer’s disease, we constructed a novel adenovirus AS1842856 in vivo vaccine encoding ten repeats of A beta 3-10 and CpG motif as an adjuvant and

investigated the immune response in BALB/c mouse after intranasal inoculation with this vaccine. The Ad-10 x A beta 3-10-CpG induces an IgG1 predominant humoral response and production of IL-4 and IL-10 in splenocytes in vitro, indicating a Th2-polarized immune response. Stimulation this website of splenocytes with A beta 3-10 peptide induces robust proliferation but not with full-length A beta 42 peptide, demonstrating that Ad-10 x A beta 3-10-CpG does not induces A beta 42 specific T cell immune response. The findings raise the possibility that the adenovirus

vaccine Ad-10 x A beta 3-10-CpG could be a safe and effective alternative for immunotherapy in Alzheimer’s disease. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.”
“Objective: We have compared the effectiveness, time required for de-airing, and safety of a newly developed de-airing technique for open left heart surgery (Lund technique) with a standardized carbon dioxide insufflation technique.

Methods: Twenty patients undergoing elective open aortic valve surgery were randomized prospectively to the Lund technique (Lund group, n = 10) or the carbon dioxide insufflation technique (carbon dioxide group, n = 10). Both groups were monitored intraoperatively during de-airing and for 10 minutes after weaning during from cardiopulmonary bypass

by transesophageal echocardiography and online transcranial Doppler for the severity and the number of gas emboli, respectively. The systemic arterial partial pressure of carbon dioxide and pH were also monitored in both groups before, during, and after cardiopulmonary bypass.

Results: The severity of gas emboli observed on transesophageal echocardiography and the number of microembolic signals recorded by transcranial Doppler were significantly lower in the Lund group during the de-airing procedure (P = .00634) and in the first 10 minutes after weaning from cardiopulmonary bypass (P = .000377). Furthermore, the de-airing time was significantly shorter in the Lund group (9 vs 15 minutes, P – .001). The arterial pH during the cooling phase of cardiopulmonary bypass was significantly lower in the carbon dioxide group (P = .