Exposure to SEA 4 hr prior to OVA sensitization triggers an increased accumulation of eosinophils in bronchoalveolar lavage fluid, bone marrow, and lung tissue at 24 hr after OVA re-challenge (93). Our intention was to present the current status of knowledge regarding the use of SEA as a tool for increasing immune tolerance to proteins that function as allergens or autoantigens in different diseases. MK-2206 solubility dmso Current studies are still trying to determine the exact route of administration that could provide a benefit in human or animal therapy. In our opinion, the oral route and the sequence of SEA followed by the incriminated peptide or protein can provide
a solution to augmenting the immune regulatory responses. Still, some difficulties remain to be solved. So far, only administration of SEA in the neonatal period has proven to be successful. For humans, it would be of great interest to also AZD6738 mouse improve oral tolerance in adult life. It is reasonable to foresee difficulties in establishing the appropriate dose of this potentially
toxic molecule in human therapy, both in adults and, even more so, in neonates. On the other hand, research regarding SEA could open a window to other approaches to boosting physiological ways of gaining tolerance to molecules that enter the digestive tract. This work was funded by the Romanian National Council of Scientific Research in Higher Education – CNCSIS (PD_477). “
“Vitamin A and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition intestinal CD103+ DCs to imprint tissue-specific homing programs onto activated lymphocytes is well documented, it is unclear whether vitamin A also regulates DC populations in other tissues. A study published in this issue of the European Journal of Immunology, Beijer et al. [Eur. J. Immunol. 2013. 43: 1608–1616] now demonstrates that vitamin A exerts profound effects on the subset composition of splenic DCs. By resolving that splenic
ESAMhi CD11bhi DCs are preferentially responsive to regulation by vitamin A, these novel insights not only further support the notion that ESAM expression marks two distinct lineages of splenic CD11bhi Liothyronine Sodium DCs, but also provide an important extension to our understanding of how vitamin A influences the immune system. DCs are rare, but widely distributed cells of hematopoietic origin that are specialized in capturing and presenting antigen to naïve T cells. Notably, DCs are comprised of multiple subsets that not only differ in phenotype and anatomical location, but, importantly, also exert distinct biological functions [1-3]. A useful strategy to divide these different subsets takes into consideration their relative ability to promote T-cell responses.