Laparotomy demonstrated more than twenty separate tumours along a 70 cm length

of small bowel. Histopathology demonstrated multiple similar neuroendocrine tumours as well as metastatic lymph node deposits. Case Two: Mr. XY, a 61 year old man, presented one year after Mr AB’s diagnosis with abdominal BMN673 pain, diarrhoea and hot flushes. CT scan demonstrated a soft tissue mass in his distal ileum. Histopathology from an extended right hemi colectomy demonstrated at least fourteen low-grade neuroendocrine tumours proximal to the ileocaecal valve, with metastases to nine of eighteen excised lymph nodes. Literature Review Methods: A systematic literature review was conducted using “Medline” and “Premedline” utilizing the MeSH terms “Neuroendocrine Tumour” and “Carcinoid”, with resulting articles culled based on review of title and / or abstract. Articles describing familial or genetic associations with carcinoid tumours were included. Results: The search identified 12681 articles of which 63 were thought to be potentially relevant. After review of abstracts

15 were included and reviewed in full text. BMS-907351 price The majority of these (n = 10) described familial cases not associated with MEN. Additionally, the majority of these non-MEN case series involved carcinoids of the small bowel (n = 7), followed by pulmonary (n = 2) and large bowel (n = 1). Also of note, there was only one previous published case report of familial carcinoid in Australia. Discussion: Based on a review of the literature these patients represent only the second reported case of familial carcinoid in Australia. Additionally they may also represent two new cases of an emerging syndrome of FIEC. We are also attempting to ascertain the histopathology from the third brother who died from an intra-abdominal tumour. This adds further weight to arguments for investigation of patients with abdominal symptoms who have a family history of small bowel Carcinoid, as well as the potential for an increased role of novel

oncogenes in familial small bowel Carcinoid pathogenesis. 1 Cunningham JL, Diaz de Stahl T, Sjoblom T, Westin G, Dumanski JP, Janson ET: Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic else ileal carcinoid tumours. Genes, Chromosomes and Cancer 2011; 50(2): 82–94 CJ SHUTTLEWORTH,1 M HALLAND,2 K BRISCOE3 1Basic Physician Trainee, St George Hospital, Sydney, Australia, 2Department of Gastroenterology, Mayo Clinic, Rochester Mn, 3North Coast Cancer Institute, Coffs Harbour, Australia Introduction: The North Coast Cancer Institute (NCCI) is a public oncology unit which services a population of approximately 120 000. A cluster of Carcinoid diagnoses, in particular a pair of brothers with a family history of gastrointestinal malignancy, triggered an investigation into the perceived increased incidence of Carcinoid in the area. Methodology: To investigate incidence of Carcinoid in Coffs Harbour, a review of the NCCI’s “MOSAIC” electronic record was undertaken.