for C19H15Cl2N3O2 388.2670); Anal. calcd. for C19H15Cl2N3O2: C, 58.78; H, 3.90; Cl, 18.26; N, 10.82. Found C, 58.56; H, 3.92; Cl, 18.26; N, 10.86. 6-(2-Chlorbenzyl)-1-(4-chlorphenyl)-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-one (3p) 0.02 mol (5.49 g) of hydrobromide of 1-(4-chlorphrnyl)-4,5-dihydro-1H-imidazol-2-amine (1d), 0.02 mol (5.69 g) of diethyl 2-(2-chlorobenzyl)malonate (2b), 15 mL of 16.7 % solution of HSP inhibitor drugs sodium methoxide and 60 mL of methanol were heated in a round-bottom flask equipped with a condenser and mechanic mixer in boiling for 8 h. The reaction mixture was then cooled down,
and the solvent was distilled off. The resulted solid was dissolved in 100 mL of water, and 10 % Selonsertib mw solution of hydrochloric acid was added till acidic reaction. The obtained precipitation was filtered out, washed with water, and purified by Tucidinostat solubility dmso crystallization from methanol. It was
obtained 6.99 g of 3p (90 % yield), white crystalline solid, m.p. 288–290 °C; 1H NMR (DMSO-d 6, 300 MHz,): δ = 10.51 (s, 1H, OH), 7.15–7.76 (m, 8H, CHarom), 4.02 (dd, 2H, J = 9.0, J′ = 7.6 Hz, H2-2), 4.19 (dd, 2H, J = 9.0, J′ = 7.6 Hz, H2-2), 3.56 (s, 2H, CH2benzyl); 13C NMR (DMSO-d 6, 75 MHz,): δ = 23.23 (CBz), 40.2 (C-2), 45.9 (C-3), 90.4 (C-6), 120.4, 123.3, 125.7, 125.9, 126.7, 128.5, 129.2, 130.7, 131.5, 144.4 (C7), 161.5 (C-8a), 169.5 (C-5),; EIMS m/z 389.1 [M+H]+. HREIMS (m/z) 388.1766 [M+] (calcd. for C19H15Cl2N3O2 388.2670); Anal. calcd. for C19H15Cl2N3O2: C, 58.78; H, 3.90; Cl, 18.26; N, 10.82. Found C, 58.45; H, 3.94; Cl, 18.27; N, 10.80. 6-(2-Chlorbenzyl)-1-(3,4-dichlorphenyl)-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-one (3q) 0.02 mol (6.18 g) Cyclin-dependent kinase 3 of hydrobromide of 1-(3,4-dichlorphenyl)-4,5-dihydro-1H-imidazol-2-amine (1e), 0.02 mol (5.69 g) of diethyl 2-(2-chlorobenzyl)malonate (2b), 15 mL of 16.7 % solution of sodium methoxide and 60 mL of methanol were heated in a round-bottom flask equipped with a condenser and mechanic mixer in boiling for 8 h. The reaction mixture was then cooled down, and the solvent was distilled off. The resulted solid was dissolved in 100 mL of water, and 10 % solution of hydrochloric acid
was added till acidic reaction. The obtained precipitation was filtered out, washed with water, and purified by crystallization from methanol. 222–224 °C; 1H NMR (DMSO-d 6, 300 MHz,): δ = 11.01 (s, 1H, OH) 7.05–7.65 (m, 7H, CHarom), 4.05 (dd, 2H, J = 9.1, J′ = 7.6 Hz, H2-2), 4.20 (dd, 2H, J = 9.1, J′ = 7.6 Hz, H2-2), 3.46 (s, 2H, CH2benzyl); 13C NMR (DMSO-d 6, 75 MHz,): δ = 25.9 (CBz), 39.9 (C-2), 45.4 (C-3), 92.4 (C-6), 120.3, 123.5, 125.2, 126.9, 127.3, 128.2, 131.1, 131.6, 132.2, 132.6, 154.1 (C-7), 161.1 (C-8a), 164.5 (C-5),; EIMS m/z 423.7 [M+H]+. HREIMS (m/z) 422.2516 [M+] (calcd. for C19H14Cl3N3O2 422.7160); Anal.